منابع مشابه
Nascent Ribosomes
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
متن کاملSynthetic ribosomes
1 describes the design, synthesis and operation of an artificial small-molecule capable of synthesizing peptides in a sequence-specific manner. The design of this artificial molecular machine was, in the author's own words, " inspired by the ribosome " ; 2 with several elements analogous to ribosomal protein synthesis (Fig. 1). The tRNA's of conventional translation are substituted by amino aci...
متن کاملRibosomes rebuffed
RNA polymerase doesn't make deliveries R esearchers are divided over whether RNA polymerase tracks down genes that are ready to be transcribed or whether the enzyme remains in place. Xu and Cook add to the evidence that a gene has to relocate to one of a few sites in the nucleus to be transcribed. One possibility is that the RNA polymerase, the DNA-reading enzyme, moves from gene to gene, trans...
متن کاملShiga toxin attacks bacterial ribosomes as effectively as eucaryotic ribosomes.
Several pathogenic bacteria, including Shigelladysenteriae and certain strains of Escherichia coli, produce potent class 2 ribosome inhibiting proteins (RIPs) termed Shiga toxins (Stx). The toxins are bipartite molecules composed of a single A chain (StxA) noncovalently associated with a pentamer of receptor-binding B subunits (StxB). StxA and Stx1A from E. coli are protoxins. Proteolysis gener...
متن کاملRibosomes take control.
T he ribosome plays a universally conserved role in catalyzing the translation of all mRNAs in every cell across all kingdoms of life. It is therefore not surprising that the ribosome is considered one of the most complex and elaborately formed “molecular machines” in the cell, whose biogenesis is extraordinarily orchestrated, requiring all three RNA polymerases and more than 150 nonribosomal f...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2003
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(03)00333-2